Catalog No.: PC-61888Not For Human Use, Lab Use Only.
Filibuvir (PF-00868554, PF-868554) is a nonnucleoside, potent and selective, orally available HCV NS5B inhibitor with IC50 of 19 nM, EC50 of 75 nM (genotype 1b-Con1 replicon).
Filibuvir (PF-00868554, PF-868554) is a nonnucleoside, potent and selective, orally available HCV NS5B inhibitor with IC50 of 19 nM, EC50 of 75 nM (genotype 1b-Con1 replicon).
Filibuvir has potent in vitro antiviral activity against a majority (95.8%) of genotype 1a and 1b replicons with an overall mean EC50 of 59 nM, without cytotoxic effect in several human cell lines (CC50>320 uM).
Filibuvir exhibits good pharmacokinetic properties in preclinical animal species.
