Chemical Structure : Flecainide
CAS No.: 54143-55-4
Catalog No.: PC-70213Not For Human Use, Lab Use Only.
Flecainide is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.
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Flecainide is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.
Flecainide also inhibits ryanodine receptor 2 (RyR2), reduces calcium sparks and thus arrhythmogenic calcium waves in the heart.
M.Wt | 414.343 | |
Formula | C17H20F6N2O3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide |
1. Hilliard FA, et al. J Mol Cell Cardiol. 2010 Feb;48(2):293-301.
2. Salvage SC, et al. Acta Physiol (Oxf). 2015 Jul;214(3):361-75.
3. Salvage SC, et al. Br J Pharmacol. 2017 Apr 3. doi: 10.1111/bph.13807.
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