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Flecainide

Chemical Structure : Flecainide

CAS No.: 54143-55-4

Flecainide (R818)

Catalog No.: PC-70213Not For Human Use, Lab Use Only.

Flecainide is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Flecainide is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.
Flecainide also inhibits ryanodine receptor 2 (RyR2), reduces calcium sparks and thus arrhythmogenic calcium waves in the heart.

Physicochemical Properties

M.Wt 414.343
Formula C17H20F6N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide

References

1. Hilliard FA, et al. J Mol Cell Cardiol. 2010 Feb;48(2):293-301.

2. Salvage SC, et al. Acta Physiol (Oxf). 2015 Jul;214(3):361-75.

3. Salvage SC, et al. Br J Pharmacol. 2017 Apr 3. doi: 10.1111/bph.13807.

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