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Flecainide acetate

Chemical Structure : Flecainide acetate

CAS No.: 54143-56-5

Flecainide acetate (R-818, R818)

Catalog No.: PC-45252Not For Human Use, Lab Use Only.

A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.
Flecainide acetate also inhibits ryanodine receptor 2 (RyR2), reduces calcium sparks and thus arrhythmogenic calcium waves in the heart.

Physicochemical Properties

M.Wt 474.3947
Formula C19H24F6N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, acetate (1:1)

References

1. Hilliard FA, et al. J Mol Cell Cardiol. 2010 Feb;48(2):293-301.

2. Salvage SC, et al. Acta Physiol (Oxf). 2015 Jul;214(3):361-75.

3. Salvage SC, et al. Br J Pharmacol. 2017 Apr 3. doi: 10.1111/bph.13807.

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