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Flucopride

Chemical Structure : Flucopride

CAS No.: 1639925-34-0

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Flucopride

Catalog No.: PC-23392Not For Human Use, Lab Use Only.

Flucopride is a potent, dual serotonin subtype 4 receptor (5-HT4R) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 9.6 nM (5-HT4R) and IC50 of 24 nM (hAChE).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Flucopride is a potent, dual serotonin subtype 4 receptor (5-HT4R) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 9.6 nM (5-HT4R) and IC50 of 24 nM (hAChE).
Flucopride is 250 times more potent for AChE (IC50 = 24 nM) than for (eq)BuChE (IC50 = 6.2 μM).
Flucopride promotes the non-amyloidogenic processing of APP in COS-7 transiently expressing (h)5-HT4 receptors with EC50 of 23.0 nM.
Flucopride (10 mg/kg) decreases spontaneous locomotor activity in vivo, reverses the scopolamine-induced spontaneous alternation deficit.

Physicochemical Properties

M.Wt 376.52
Formula C22H33FN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-amino-5-fluoro-2-methoxyphenyl)-3-(1-(cyclohexylmethyl)piperidin-4-yl)propan-1-one

References

1. Rochais C, et al. Eur J Med Chem. 2024 Oct 18;280:116975.

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