Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Flucopride
Catalog No.: PC-23392Not For Human Use, Lab Use Only.
Flucopride is a potent, dual serotonin subtype 4 receptor (5-HT4R) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 9.6 nM (5-HT4R) and IC50 of 24 nM (hAChE).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Flucopride is a potent, dual serotonin subtype 4 receptor (5-HT4R) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 9.6 nM (5-HT4R) and IC50 of 24 nM (hAChE).
Flucopride is 250 times more potent for AChE (IC50 = 24 nM) than for (eq)BuChE (IC50 = 6.2 μM).
Flucopride promotes the non-amyloidogenic processing of APP in COS-7 transiently expressing (h)5-HT4 receptors with EC50 of 23.0 nM.
Flucopride (10 mg/kg) decreases spontaneous locomotor activity in vivo, reverses the scopolamine-induced spontaneous alternation deficit.
| M.Wt | 376.52 | |
| Formula | C22H33FN2O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Rochais C, et al. Eur J Med Chem. 2024 Oct 18;280:116975.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
