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Fludarabine

Chemical Structure : Fludarabine

CAS No.: 21679-14-1

Fludarabine (F-ara-A, NSC 118218)

Catalog No.: PC-22565Not For Human Use, Lab Use Only.

Fludarabine (NSC118218) is a fluorinated purine analogue ands DNA synthesis inhibitor with antineoplastic activities, inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.

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Biological Activity

Fludarabine (NSC118218) is a fluorinated purine analogue ands DNA synthesis inhibitor with antineoplastic activities.
Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.
Fludarabine also inhibits N-acetyltransferase 10 (NAT10), shows anti-leukaemia effects both in vitro and in vivo.

Physicochemical Properties

M.Wt 285.24
Formula C10H12FN5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,3S,4S,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

References

1. Liang YB, et al. Mol Med Rep. 2017 Nov;16(5):6405-6411.

2. Sanhes L, et al. Leukemia. 2003 Jun;17(6):1104-11.

3. Frank DA, et al. Nat Med. 1999;5(4):444-447.

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