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Chemical Structure : Fluorofolin
Catalog No.: PC-22130Not For Human Use, Lab Use Only.
Fluorofolin is a potent bacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 2.5 nM for purified E. coli DHFR (FolA), exhibits potent activity against P. aeruginosa PA14 with MIC of 3.1 ug/mL.
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Fluorofolin is a potent bacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 2.5 nM for purified E. coli DHFR (FolA), exhibits potent activity against P. aeruginosa PA14 with MIC of 3.1 ug/mL.
Fluorofolin has broad-spectrum antibiotic activity, is capable of inhibiting growth of two other strains of P. aeruginosa, PA01 and ATTC 27853, as well as all 5 of the ESKAPE28 pathogens at <50 ug/mL.
Fluorofolin exhibits modest specificity with IC50 of 14.0 nM for purified human DHFR.
Fluorofolin inhibits folate metabolism in P. aeruginosa cells.
Fluorofolin inhibits murine thigh infection of P. aeruginosa, selectively targets P. aeruginosa with exogenous thymine.
| M.Wt | 308.32 | |
| Formula | C16H13FN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chain C, et al. Nat Microbiol. 2024 Apr 9. doi: 10.1038/s41564-024-01665-2.
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