Chemical Structure : Fluorothiazinone
CAS No.:
1370706-59-4
Fluorothiazinone
Catalog No.: PC-26780Not For Human Use, Lab Use Only.
Fluorothiazinone is a small molecule antivirulent compound that suppresses the formation of biofilms, inhibits the type III secretion system (T3SS) in Gram-negative bacteria.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Fluorothiazinone is a small molecule antivirulent compound that suppresses the formation of biofilms, inhibits the type III secretion system (T3SS) in Gram-negative bacteria.
Fluorothiazinone inhibits motility of P. aeruginosa, P. mirabilis, and E. coli in a dose-dependent manner.
Fluorothiazinone selectively inhibits flagellum-based motility in Gram-negative bacteria.
Fluorothiazinone interferes with flagellum biosynthesis rather than disruption of rotation.
Physicochemical Properties
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M.Wt
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421.42
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Formula
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C19H17F2N3O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2,4-difluorophenyl)-4-(3-ethoxy-4-hydroxybenzyl)-5-oxo-5,6-dihydro-4H-1,3,4-thiadiazine-2-carboxamide
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References
1. Tsarenko SV, et al. J Antibiot (Tokyo). 2023 Jul;76(7):397-405.
2. Zigangirova NA, et al. Antibiotics (Basel). 2024 May 22;13(6):476.
3. Slonov A, et al. Antibiotics (Basel). 2025 Aug 11;14(8):820.
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