Catalog No.: PC-38394Not For Human Use, Lab Use Only.
Fosgonimeton (ATH-1017, ATH-1001 prodrug) is a highly specific, small-molecule positive modulator of the HGF/MET neurotrophic system, is a prodrug that rapidly converts into the active metabolite ATH-1001 in plasma.
Fosgonimeton (ATH-1017, ATH-1001 prodrug) is a highly specific, small-molecule positive modulator of the HGF/MET neurotrophic system, is a prodrug that rapidly converts into the active metabolite ATH-1001 in plasma.
ATH-1001 crosses the blood-brain barrier and enhances the interaction of HGF with its receptor tyrosine kinase MET, inducing downstream signaling through PI3k/Akt and MAPK pathways and augmenting NMDA receptor-mediated long-term potentiation through PKC.
Fosgonimeton (ATH-1017) demonstrates potential with Alzheimer's disease (AD) and dementia, potentially improving dementia symptoms and altering disease progression by reversing synaptic disconnection and neuronal loss.
