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Foslinanib

Chemical Structure : Foslinanib

CAS No.: 1256037-60-1

Foslinanib (TRX-818, TRX818, CVM-1118)

Catalog No.: PC-35450Not For Human Use, Lab Use Only.

Foslinanib (TRX-818, CVM-1118) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1.

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    Biological Activity

    Foslinanib (TRX-818, CVM-1118) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1.
    Foslinanib (TRX-818, CVM-1118) induces cancer cell apoptosis and inhibits cancer cell proliferation,.
    Foslinanib (TRX-818, CVM-1118) also prevents tumor cell VM by blocking the formation of vasculogenic-like tubular structures through an as of yet undetermined mechanism of action.

    Physicochemical Properties

    M.Wt 365.253
    Formula C16H13FNO6P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(3-fluorophenyl)-6-methoxy-4-oxo-1,4-dihydroquinolin5-yl dihydrogen phosphate

    References

    1. Lifen Shen, et al. Pathol Oncol Res. 2023 Jun 7:29:1611038.

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