Fosmanogepix (APX001) | Gwt1 inhibitor

Chemical Structure : Fosmanogepix

Catalog No.: PC-35452Not For Human Use, Lab Use Only.

Fosmanogepix (APX001, E1211) is a novel antifungal agent, the prodrug form of Manogepix, which inhibits the fungal protein Gwt1.

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Biological Activity

Fosmanogepix (APX001, E1211) is a novel antifungal agent, the prodrug form of Manogepix, which inhibits the fungal protein Gwt1.

M.Wt	468.406
Formula	C22H21N4O6P
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyridinium, 2-amino-1-[(phosphonooxy)methyl]-3-[3-[[4-[(2-pyridinyloxy)methyl]phenyl]methyl]-5-isoxazolyl]-, inner salt

1. Hager CL, et al. Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02319-17.
2. Dai X, et al. Nat Commun. 2024 Oct 24;15(1):9194.