Fosnetupitant | NK1R antagonist | Probechem Biochemicals

Chemical Structure : Fosnetupitant

Fosnetupitant (FosNTP, Pronetupitant)

Catalog No.: PC-27025Not For Human Use, Lab Use Only.

Fosnetupitant is a phosphorylated prodrug formulation of netupitant and selective neurokinin-1 receptor (NK1R) antagonist with pKi of 9.5, >1000-fold selective over NK3R.

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Biological Activity

Fosnetupitant is a phosphorylated prodrug formulation of netupitant and selective neurokinin-1 receptor (NK1R) antagonist with pKi of 9.5, >1000-fold selective over NK3R.

Physicochemical Properties

M.Wt	688.61
Formula	C31H35F6N4O5P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methylpiperazin-1-ium-1-yl)methyl hydrogen phosphate

References

1. Inano H, et al. Biol Pharm Bull. 2024 Mar 25;47(3):692-697.

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Fosnetupitant (FosNTP, Pronetupitant)

Biological Activity

Physicochemical Properties

References

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