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Foxy-5

Chemical Structure : Foxy-5

CAS No.: 881188-51-8

Foxy-5 (formyl-Met-Asp-Gly-Cys-Glu-Leu;Foxy5)

Catalog No.: PC-61759Not For Human Use, Lab Use Only.

Foxy-5 is a novel Wnt-5A mimicking hexapeptide that inhibits breast cancer metastasis in vivo by targeting cell motility.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Foxy-5 is a novel Wnt-5A mimicking hexapeptide that inhibits breast cancer metastasis in vivo by targeting cell motility; also significantly inhibits the initial metastatic dissemination of prostate cancer cells to regional and distal lymph nodes, specifically targets invasion without affecting apoptosis or viability of WNT5A-low prostate cancer cells.

Breast Cancer

Phase 1 Clinical

Physicochemical Properties

M.Wt 694.77
Formula C26H42N6O12S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,5S,8R,14S)-5-(2-carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butanamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecanedioic acid

References

1. Säfholm A, et al. Clin Cancer Res. 2008 Oct 15;14(20):6556-63.

2. Ford CE, et al. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3919-24.

3. Canesin G, et al. PLoS One. 2017 Sep 8;12(9):e0184418.

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