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Fumagillin

Chemical Structure : Fumagillin

CAS No.: 23110-15-8

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Fumagillin (Amebacilin, NSC9168)

Catalog No.: PC-22787Not For Human Use, Lab Use Only.

Fumagillin (NSC9168) is an antimicrobial compound that covalently binds and inhibits the methionine aminopeptidase MetAP-2, inhibits angiogenesis and cancer cell proliferation.

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5 mg $178 In stock
10 mg $298 In stock
25 mg $498 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Fumagillin (NSC9168) is an antimicrobial compound that covalently binds and inhibits the methionine aminopeptidase MetAP-2, inhibits angiogenesis and cancer cell proliferation.
Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.

Physicochemical Properties

M.Wt 458.55
Formula C26H34O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2E,4E,6E,8E)-10-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraenoic acid

References

1. Sin N, et al. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6099-103.

2. Griffith EC, et al. Chem Biol. 1997 Jun;4(6):461-71.

3. Griffith EC, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15183-8.

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