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Fumarase-IN-2 sodium

Chemical Structure : Fumarase-IN-2 sodium

CAS No.: 2070009-45-7

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Fumarase-IN-2 sodium (Fumarase inhibitor 2 sodium)

Catalog No.: PC-42019Not For Human Use, Lab Use Only.

Fumarase-IN-2 sodium is a cell-permeable small molecule inhibitor of Fumarase (fumarate hydratase), an enzyme of the tricarboxylic acid cycle (TCA cycle).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Fumarase-IN-2 sodium is a cell-permeable small molecule inhibitor of Fumarase (fumarate hydratase), an enzyme of the tricarboxylic acid cycle (TCA cycle).
Fumarase-IN-2 sodium elicits a nutrient-dependent cytotoxicity in a number of cancer cell lines.
Fumarase-IN-2 sodium displays increased growth-inhibitory activity toward SW620 cell line grown in the absence of glucose (mean IC50=2.2 uM).

Physicochemical Properties

M.Wt 440.4668
Formula C25H25N2NaO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: 10.66 mg/mL
Chemical Name/SMILES

3aH-Indole-3a-carboxylic acid, 1-([1,1'-biphenyl]-4-ylmethyl)-1,2,3,4,5,6-hexahydro-3-[2-(methylamino)-2-oxoethyl]-2-oxo-, (3R,3aS)-rel-,sodium salt

References

1. Takeuchi T, et al. J Am Chem Soc. 2015 Jan 21;137(2):564-7.

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