Fusicoccin-A |CAS:20108-30-9 Probechem Biochemicals

Chemical Structure : Fusicoccin-A

CAS No.: 20108-30-9

Fusicoccin-A (Fusicoccin, FC-A)

Catalog No.: PC-61233Not For Human Use, Lab Use Only.

Fusicoccin-A is a small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.

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Biological Activity

Fusicoccin-A is a small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.
Fusicoccin-A induces GCN1 turnover and neurite outgrowth, stimulates axon growth in vitro and regeneration in vivo.
Fusicoccin-A stabilizes the interaction between 14-3-3 and CFTR by selectively interacting with a secondary binding motif of CFTR (pS753).

Physicochemical Properties

M.Wt	680.82
Formula	C36H56O12
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	α-D-Glucopyranoside, (1S,4R,5R,6R,6aS,9S,10aR)-3-[(1S)-2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethyldicyclopenta[a,d]cycloocten-4-yl 6-O-(1,1-dimethyl-2-propenyl)-, 3-acetate (9CI)

References

1. Kaplan A, et al. Neuron. 2017 Mar 8;93(5):1082-1093.e5.

2. Stevers LM, et al. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1152-61.

Fusicoccin-A (Fusicoccin, FC-A)

Biological Activity

Physicochemical Properties

References

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