G-5555 is a potent and selective p21-activated kinase 1 (PAK1) inhibitor (Ki=3.7 nM).
G-5555 showes excellent kinase selectivity and inhibits only eight out of the 235 kinases with inhibition >70% at 0.1 uM.
G-5555 inhibits S298 phosphorylation of MEK1 in EBC1 cells with IC50 of 69 nM.
G-5555 shows improved potency and selectivity than FRAX1036 (Cat#PC-45644); shows good vivo PK/PD effects.
