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Chemical Structure : G-5555
CAS No.: 1648863-90-4
Catalog No.: PC-45665Not For Human Use, Lab Use Only.
G-5555 is a potent and selective p21-activated kinase 1 (PAK1) inhibitor (Ki=3.7 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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G-5555 is a potent and selective p21-activated kinase 1 (PAK1) inhibitor (Ki=3.7 nM).
G-5555 showes excellent kinase selectivity and inhibits only eight out of the 235 kinases with inhibition >70% at 0.1 uM.
G-5555 inhibits S298 phosphorylation of MEK1 in EBC1 cells with IC50 of 69 nM.
G-5555 shows improved potency and selectivity than FRAX1036 (Cat#PC-45644); shows good vivo PK/PD effects.
| M.Wt | 492.9574 | |
| Formula | C25H25ClN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 27 mg/mL |
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| Chemical Name/SMILES |
Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)- |
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1. Ndubaku CO, et al. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6.
2. Rudolph J, et al. J Med Chem. 2016 Jun 9;59(11):5520-41.
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