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Chemical Structure : G-744
Catalog No.: PC-60364Not For Human Use, Lab Use Only.
G-744 is a highly potent, selective inhibitor of BTK with biochemical Ki of 1.28 nM.
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G-744 is a highly potent, selective inhibitor of BTK with biochemical Ki of 1.28 nM; demonstrates >1,000-fold selectivity against a panel 285 kinase (exception with EphA7 and Fgr, 400-800 fold); prevents BCR-mediated CD86 induction (EC50=64 nM), also inhibits BCR-stimulated B-cell proliferation in human B-cells (EC50=22 nM), abrogates production of TNFα in human monocytes (EC50=33 nM); demonstrates efficacy in the developing CIA model in rats.
| M.Wt | 527.643 | |
| Formula | C29H29N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang X, et al. ACS Med Chem Lett. 2017 May 3;8(6):608-613.
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