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Chemical Structure : G007-LK
CAS No.: 1380672-07-0
Catalog No.: PC-43035Not For Human Use, Lab Use Only.
G007-LK is a potent, specific, metabolically stable TNKS1/2 inhibitor with IC50 of 46 nM and 25 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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G007-LK is a potent, specific, metabolically stable TNKS1/2 inhibitor with IC50 of 46 nM and 25 nM, respectively.
G007-LK reduces Wnt/β-catenin signaling by preventing poly(ADP-ribosyl)ation-dependent AXIN degradation, thereby promoting β-catenin destabilization.
G007-LK effectively blocks ligand-driven Wnt/β-catenin signaling in cell culture and displays approximately 50% inhibition of APC mutation-driven signaling in most CRC cell lines, inhibits the g of mouse intestinal organoids cultured ex vivo with IC50 of 80 nM.
G007-LK inhibits in vivo tumor growth in a subset of APC-mutant CRC xenograft models.
| M.Wt | 529.9576 | |
| Formula | C25H16ClN7O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Benzonitrile, 4-[5-[(1E)-2-[4-(2-chlorophenyl)-5-[5-(methylsulfonyl)-2-pyridinyl]-4H-1,2,4-triazol-3-yl]ethenyl]-1,3,4-oxadiazol-2-yl]- |
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1. Voronkov A, et al. J Med Chem. 2013 Apr 11;56(7):3012-23.
2. Lau T, et al. Cancer Res. 2013 May 15;73(10):3132-44.
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