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Chemical Structure : G0775
Catalog No.: PC-22138Not For Human Use, Lab Use Only.
G0775 is a novel potent, broad-spectrum antibiotic against Gram-negative bacteria (MDR K. pneumoniae CDC 0106, MIC=0.5 ug/mL), inhibits the Gram-negative type I signal peptidase (SPase) LepB with Ki of 0.44 nM, a new antibiotic target.
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G0775 is a novel potent, broad-spectrum antibiotic against Gram-negative bacteria (MDR K. pneumoniae CDC 0106, MIC=0.5 ug/mL), inhibits the Gram-negative type I signal peptidase (SPase) LepB with Ki of 0.44 nM, a new antibiotic target.
G0775 is at least 500-fold more potent than arylomycin A-C16 against the ESKAPE pathogens E. coli and K. pneumoniae as well as against related pathogens from the same family.
G0775 is active against a panel of 49 MDR clinical isolates of E. coli and K. pneumonia.
G0775 binds the LepB protease domain to form an irreversible covalent bond with catalytic lysine 146.
G0775 is bacteriostatic at 2 mg/kg and bactericidal at 20 mg/kg, protects mice from a lethal challenge of K. pneumoniae Zstrain ATCC 43816 in a mucin peritonitis model.
| M.Wt | 890.06 | |
| Formula | C47H59N11O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Peter A Smith, et al. Nature. 2018 Sep;561(7722):189-194.
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