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Chemical Structure : G15
CAS No.: 1161002-05-6
Catalog No.: PC-60268Not For Human Use, Lab Use Only.
G-15 (GPR30 inhibitor G15, G15) is a potent, selective GPER/GPR30 antagonist with Ki of 20 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
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G15 (GPR30 inhibitor G15) is a potent, selective GPER/GPR30 antagonist with Ki of 20 nM.
G15 displays little binding affinity to ERα or ERβ at 10 uM.
G15 inhibits the G-1-mediated activation of PI3K, also effectively blocks the estrogen-mediated response in GPR30-transfected cells.
G15 also blocks G-1-induced proliferation in the ovariectomized mouse model.
| M.Wt | 370.24 | |
| Formula | C19H16BrNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3AS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline |
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1. Dennis MK, et al. J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):358-66.
2. Dennis MK, et al. Nat Chem Biol. 2009 Jun;5(6):421-7.
3. Sharma G, et al. Endocrinology. 2011 Aug;152(8):3030-9.
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