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Chemical Structure : GANT 58
CAS No.: 64048-12-0
Catalog No.: PC-43461Not For Human Use, Lab Use Only.
GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM.
GANT 58 efficiently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth in an in vivo xenograft model of human prostate cancer cells harboring downstream activation of the Hh pathway.
| M.Wt | ||
| Formula | C24H16N4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyridine, 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis- |
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1. Lauth M, et al. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60.
2. Hassounah NB, et al. Clin Cancer Res. 2012 May 1;18(9):2429-35.
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