Catalog No.: PC-42735Not For Human Use, Lab Use Only.
GAP-134 (Danegaptide) is a potent, orally active gap-junction modifier, prevents significantly conduction velocity slowing at 10 nM compared with vehicle.
GAP-134 (Danegaptide) is a potent, orally active gap-junction modifier, prevents significantly conduction velocity slowing at 10 nM compared with vehicle.
GAP-134 (Danegaptide) has highly desirable in vitro and in vivo safety profile including (1) lack of direct effects on membrane ion currents, hERG inhibition, and CYP450 liabilities, (2) negative AMES result, (3) a benign NovaScreen profile, and (4) no effects on systemic hemodynamics.
Physicochemical Properties
M.Wt
291.3025
Formula
C14H17N3O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
L-Proline, glycyl-4-(benzoylamino)-, (4R)-
References
1. Butera JA, et al. J Med Chem. 2009 Feb 26;52(4):908-11.
2. Rossman EI, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33.
