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Chemical Structure : GAT1508
Catalog No.: PC-38131Not For Human Use, Lab Use Only.
GAT1508 (GAT-1508) is a potent, specific activator for brain-expressed GIRK1/2 channels (EC50=75 nM), specifically activates the brain GIRK1/2 over the cardiac GIRK1/4.
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GAT1508 (GAT-1508) is a potent, specific activator for brain-expressed GIRK1/2 channels (EC50=75 nM), specifically activates the brain GIRK1/2 over the cardiac GIRK1/4.
GAT1508 is an allosteric modulator of channel–phosphatidylinositol 4,5-bisphosphate interactions.
GAT1508 effectively extinguished conditioned fear in rodents and lacked cardiac and behavioral side effects, suggesting its potential for use in pharmacotherapy for post-traumatic stress disorder.
| M.Wt | 377.26 | |
| Formula | C15H13BrN4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xu Y, et al. J Biol Chem. 2020 Mar 13;295(11):3614-3634.
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