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GB111-NH2

Chemical Structure : GB111-NH2

CAS No.: 956479-18-8

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GB111-NH2 (Z-Phe-Lys-AOMK)

Catalog No.: PC-61355Not For Human Use, Lab Use Only.

GB111-NH2 (Z-Phe-Lys-AOMK) is a novel cysteine cathepsin inhibitor that blocks the activity of cathepsins B, L and S.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GB111-NH2 (Z-Phe-Lys-AOMK) is a novel cysteine cathepsin inhibitor that blocks the activity of cathepsins B, L and S.
GB111-NH2 (Z-Phe-Lys-AOMK) inhibits autophagy and increases oxidative stress, specifically trigger macrophage cell death.

Physicochemical Properties

M.Wt 573.68
Formula C33H39N3O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-7-amino-3-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-2-oxoheptyl 2,6-dimethylbenzoate

References

1. Salpeter SJ, et al. Oncogene. 2015 Dec 10;34(50):6066-78.

2. Blum G, et al. Nat Chem Biol. 2005 Sep;1(4):203-9.

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