Chemical Structure : GB1908
CAS No.:
2573135-31-4
GB1908
(GB-1908)
Catalog No.: PC-22405Not For Human Use, Lab Use Only.
GB1908 is a potent, selective and orally available galectin-1 (Gal-1) inhibitor with Kd of 57 nM and 72 nM for human and mouse Gal-1 respectively in fluorescence polarization assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GB1908 is a potent, selective and orally available galectin-1 (Gal-1) inhibitor with Kd of 57 nM and 72 nM for human and mouse Gal-1 respectively in fluorescence polarization assays.
GB1908 shows >100-fold selectivity over all galectin subtypes except the C terminus of galectin-4 (8-fold).
GB1908 potently inhibits galectin-1-induced apoptosis in Jurkat cells with IC50 of 0.85 uM, 3-fold improvement over that observed for GB1490 (TD-139).
GB1908 (30 mg/kg b.i.d) significantly inhibits LL/2 primary lung tumor growth in syngeneous mouse model.
Physicochemical Properties
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M.Wt
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505.39
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Formula
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C18H18Cl2N4O5S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(1-((2R,3R,4S,5R,6R)-2-((3,4-dichlorophenyl)thio)-5-hydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-4-yl)thiazol-2-ol
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References
1. Zetterberg FR, et al. J Med Chem. 2024 May 28. doi: 10.1021/acs.jmedchem.4c00485.
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