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Chemical Structure : GB1908
Catalog No.: PC-22405Not For Human Use, Lab Use Only.
GB1908 is a potent, selective and orally available galectin-1 (Gal-1) inhibitor with Kd of 57 nM and 72 nM for human and mouse Gal-1 respectively in fluorescence polarization assays.
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GB1908 is a potent, selective and orally available galectin-1 (Gal-1) inhibitor with Kd of 57 nM and 72 nM for human and mouse Gal-1 respectively in fluorescence polarization assays.
GB1908 shows >100-fold selectivity over all galectin subtypes except the C terminus of galectin-4 (8-fold).
GB1908 potently inhibits galectin-1-induced apoptosis in Jurkat cells with IC50 of 0.85 uM, 3-fold improvement over that observed for GB1490 (TD-139).
GB1908 (30 mg/kg b.i.d) significantly inhibits LL/2 primary lung tumor growth in syngeneous mouse model.
| M.Wt | 505.39 | |
| Formula | C18H18Cl2N4O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zetterberg FR, et al. J Med Chem. 2024 May 28. doi: 10.1021/acs.jmedchem.4c00485.
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