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GB2095

Chemical Structure : GB2095

CAS No.: 2574415-75-9

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GB2095 (GB-2095)

Catalog No.: PC-23627Not For Human Use, Lab Use Only.

GB2095 is a highly potent, selective and in vivo active galectin-3 (Gal-3) inhibitor with Kd of 36 nM (human Gal-3), 14-fold selectivity for galectin-3 over all other galectins.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GB2095 is a highly potent, selective and in vivo active galectin-3 (Gal-3) inhibitor with Kd of 36 nM (human Gal-3), 14-fold selectivity for galectin-3 over all other galectins.
GB2095 shows Kd of 350 nM for mouse Gal-3, 100-fold selective over mouse Gal-1.
GB2095 inhibits the growth of 4T1 breast and B16–F10 melanoma tumors in syngeneic mouse cancer models.
GB2095 is a new tool to investigate galectin-3 pharmacology in in vivo mouse models.

Physicochemical Properties

M.Wt 548.78
Formula C20H17BrClF2N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3R,4S,5R,6R)-2-((5-bromopyridin-3-yl)thio)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-pyrazol-1-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol

References

1. Peterson K, et al. J Med Chem. 2024 Dec 12. doi: 10.1021/acs.jmedchem.4c01747.

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