Catalog No.: PC-45766Not For Human Use, Lab Use Only.
Paxalisib (GDC-0084, RG7666) is a potent, selective, brain penetrant dual inhibitor of class I PI3Ks and mTOR with Ki of 2/46/3/10/70 nM for PI3Kα/β/δ/γ/mTOR, respectively.
Paxalisib (GDC-0084, RG7666) is a potent, selective, brain penetrant dual inhibitor of class I PI3Ks and mTOR with Ki of 2/46/3/10/70 nM for PI3Kα/β/δ/γ/mTOR, respectively.
Paxalisib (GDC-0084, RG7666) is highly selective against a panel of 229 kinases (IC50>1 uM).
Paxalisib (GDC-0084, RG7666) shows antiproliferative (EC50 =0.3-1.1 uM) in 5 GBM cell lines.
Paxalisib (GDC-0084, RG7666) significantly and dose-dependently inhibits tumor growth in a subcutaneous U87 tumor xenograft model of glioblastoma in mice.
