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Chemical Structure : GDC-0134
CAS No.: 1637394-01-4
Catalog No.: PC-72890Not For Human Use, Lab Use Only.
GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $218 | In stock | |
| 5 mg | $388 | In stock | |
| 10 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12).
GDC‐0134 blocks DLK activity in cellular assays and in animal models of neuronal injury.
Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS).
| M.Wt | 440.403 | |
| Formula | C19H20F4N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-2-(3,3-difluoropyrrolidin-1-yl)pyrimidin-4-yl)-3-(difluoromethoxy)pyridin-2-amine |
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1. Jonathan S Katz, et al. Ann Clin Transl Neurol. 2022 Jan;9(1):50-66.
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