Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : GDC-0276
CAS No.: 1494581-70-2
Catalog No.: PC-72192Not For Human Use, Lab Use Only.
GDC-0276 (GDC 0276) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.1 nM (hNaV1.7), cellular sodium influx IC50 of 49 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
GDC-0276 (GDC 0276) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.1 nM (hNaV1.7), cellular sodium influx IC50 of 49 nM.
GDC-0276 displays 18-fold selectivity over NaV1.5 (cellular sodium influx IC50=870 nM), as well as 26-1200-fold selectivity over NaV1.1/1.2/1.6 (potency measured by voltage clamp).
GDC-0276 showed a concentration dependent reduction in nociceptive events, with a EC50 of 1.7 μM in inherited erythromelalgia (IEM) mouse model.
| M.Wt | 462.58 | |
| Formula | C24H31FN2O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO (4.6 mg/mL) |
|
| Chemical Name/SMILES |
4-((Adamantan-1-yl)methoxy)-N-(azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluorobenzamide |
|
1. Brian S Safina, et al. J Med Chem. 2021 Mar 25;64(6):2953-2966.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
