Catalog No.: PC-72192Not For Human Use, Lab Use Only.
GDC-0276 (GDC 0276) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.1 nM (hNaV1.7), cellular sodium influx IC50 of 49 nM.
GDC-0276 (GDC 0276) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.1 nM (hNaV1.7), cellular sodium influx IC50 of 49 nM.
GDC-0276 displays 18-fold selectivity over NaV1.5 (cellular sodium influx IC50=870 nM), as well as 26-1200-fold selectivity over NaV1.1/1.2/1.6 (potency measured by voltage clamp).
GDC-0276 showed a concentration dependent reduction in nociceptive events, with a EC50 of 1.7 μM in inherited erythromelalgia (IEM) mouse model.
