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Chemical Structure : GDC-0310
CAS No.: 1788063-52-4
Catalog No.: PC-72191Not For Human Use, Lab Use Only.
GDC-0310 (GDC 0310 ) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.8 nM (hNaV1.7), cellular sodium influx IC50 of 16 nM.
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|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $728 | In stock | |
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GDC-0310 (GDC 0310 ) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.8 nM (hNaV1.7), cellular sodium influx IC50 of 16 nM.
GDC-0310 displays 94-fold selectivity over NaV1.5 (cellular sodium influx IC50=1500nM), as well as 63-330-fold selectivity over NaV1.1/1.2/1.6 (potency measured by voltage clamp).
GDC-0310 showed a concentration dependent reduction in nociceptive events, with a EC50 of 1.1 μM in inherited erythromelalgia (IEM) mouse model.
| M.Wt | 543.475 | |
| Formula | C25H29Cl2FN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-5-cyclopropyl-4-((1-(1-(3,5-dichlorophenyl)ethyl)piperidin-4-yl)methoxy)-2-fluoro-N-(methylsulfonyl)benzamide |
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1. Brian S Safina, et al. J Med Chem. 2021 Mar 25;64(6):2953-2966.
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