GDC-2992 | AR PROTAC | Probechem Biochemicals

Chemical Structure : GDC-2992

GDC-2992 (RO7656594)

Catalog No.: PC-24663Not For Human Use, Lab Use Only.

GDC-2992 (Compound 28A) is a potent, selective and orally active androgen receptor (AR) PROTAC degrader with DC50 of 2.7 nM, inhibits proliferation with IC50 of 9.7 nM in VCaP cells.

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Biological Activity

GDC-2992 (Compound 28A) is a potent, selective and orally active androgen receptor (AR) PROTAC degrader with DC50 of 2.7 nM, inhibits proliferation with IC50 of 9.7 nM in VCaP cells.

Physicochemical Properties

M.Wt	819.40
Formula	C45H51ClN8O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[trans-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[[4-[2-[(3S)-2,6-dioxo-3-piperidinyl]-1,2-dihydro-1-oxo-6-phthalazinyl]-1-piperazinyl]methyl]-1-piperidinyl]-

References

1. Patent WO2024107686 A1.

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GDC-2992 (RO7656594)

Biological Activity

Physicochemical Properties

References

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