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GDU-952

Chemical Structure : GDU-952

CAS No.: 2908782-62-5

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GDU-952 (GDU952)

Catalog No.: PC-21481Not For Human Use, Lab Use Only.

GDU-952 (GDU952) is a novel small molecule aryl hydrocarbon receptor (AhR) agonist, activates and induces nuclear translocation of AhR.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GDU-952 (GDU952) is a novel small molecule aryl hydrocarbon receptor (AhR) agonist, activates and induces nuclear translocation of AhR.
    GDU-952 (1 uM) treatment obviously increased CYP1A1 generation, induces nuclear translocation of AhR in RAW264.7 macrophages.
    GDU-952 decreases IgE serum levels, to inhibit pro-inflammatory cytokines such as IL-6 and TNF-α and to induce immunoregulatory effects through restoring Th1/Th2 immune balance and promoting CD4+FOXP3+regulatory T (Treg) populations in AD skin lesions.

    Physicochemical Properties

    M.Wt 284.37
    Formula C17H16O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-2-(cyclopent-1-en-1-yl)-5-(2-(thiophen-3-yl)vinyl)benzene-1,3-diol

    References

    1. Liang YH, et al. Biochem Pharmacol. 2023 Nov;217:115835.

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