GFH647 (GFH-647)

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Chemical Structure : GFH647

Catalog No.: PC-28073Not For Human Use, Lab Use Only.

GFH647 (GFH-647) is a potent, selective, reversible BTK inhibitor, potently inhibits both wild-type BTK and the clinically relevant C481S mutant.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GFH647 (GFH-647) is a potent, selective, reversible BTK inhibitor, potently inhibits both wild-type BTK and the clinically relevant C481S mutant.
GFH647 shows binding the catalytic ATP pocket in a Cys481-independent manner.
GFH647 demonstrates robust antitumor activity in xenograft models driven by either wild-type or C481S-mutant BTK.

Physicochemical Properties

M.Wt	482.95
Formula	C25H15D6ClN4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-9-(2-chloro-4-phenoxybenzoyl)-2-((methoxy-d3)methyl)-2-(methyl-d3)-1,2,4,6-tetrahydro-3H-pyrrolo[3',2':5,6]pyrido[3,4-b]pyrazin-3-one

References

1. Patent WO2022063101 A1 2022-03-31.

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GFH647 (GFH-647)

Biological Activity

Physicochemical Properties

References

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