Chemical Structure : GHN105
CAS No.:
GHN105
(GHN-105)
Catalog No.: PC-24093Not For Human Use, Lab Use Only.
GHN105 is a specific, orally bioavailable, covalent STING inhibitor, selectively targets the membrane-proximal Cys91 residue of STING, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 4.4 uM.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GHN105 is a specific, orally bioavailable, covalent STING inhibitor, selectively targets the membrane-proximal Cys91 residue of STING, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 4.4 uM.
GHN105 dose-dependently inhibits cGAS-STING signaling and type I interferon responses in cells and in vivo.
GHN105 strongly reduced dsDNA-induced phosphorylation of STING, TANK-binding kinase 1 (TBK1), and IFN regulatory factor 3 (IRF3) in murine NIH3T3 cells.
GHN105 suppressed host antiviral responses in human mesenchymal stem cells.
GHN105 exhibited on-target engagement in vivo and markedly reversed key pathological features in a delayed treatment of the acute colitis mouse model.
GHN105 has efficacy against the most common hSTING allele as well as the pathogenic variant causing STING-associated vasculopathy in infants (SAVI).
Physicochemical Properties
|
M.Wt
|
800.90
|
|
Formula
|
C41H56N2O14
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
|
Contact Us
sales@probechem.com
