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GHP-88309

Chemical Structure : GHP-88309

CAS No.: 1269267-87-9

GHP-88309 (GHP88309)

Catalog No.: PC-73390Not For Human Use, Lab Use Only.

GHP-88309 (GHP88309) is a non-nucleoside, broad-spectrum allosteric inhibitor of paramyxovirus polymerase with EC50 of 0.9 uM against HPIV3-JS RdRP.

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    Biological Activity

    GHP-88309 (GHP88309) is a non-nucleoside, broad-spectrum allosteric inhibitor of paramyxovirus polymerase with EC50 of 0.9 uM against HPIV3-JS RdRP.
    Demonstrates highly potent antiviral potency against HPIV3-JS and clinical isolates HPIV3-9R4 and HPIV3-10L3 in the primary cell/virus isolate system (EC50=0.07-0.08 uM), without cytotoxicity.
    GHP-88309 targets a conserved microdomain in the L protein, inhibiting de novo RNA synthesis.
    GHP-88309 is efficacious in well-differentiated human airway epithelium cultures grown at air-liquid interface (3D-ALI-HBTEC).
    GHP-88309 (150 mg/kg b.i.d.) is orally efficacious in HPIV disease surrogate model.
    GHP-88309 possesses unusual broad-spectrum activity against diverse paramyxoviruses including respiroviruses (i.e. HPIV1 and HPIV3) and morbilliviruses (i.e. MeV).

    Physicochemical Properties

    M.Wt 266.275
    Formula C16H11FN2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-fluoro-6-(isoquinolin-5-yl)benzamide

    References

    1. Robert M Cox, et al. Nat Microbiol. 2020 Oct;5(10):1232-1246.

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