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Chemical Structure : GIRK1/4 inhibitor 14b
Catalog No.: PC-20299Not For Human Use, Lab Use Only.
GIRK1/4 inhibitor 14b is a potent, brain-sparing GIRK1/4 inhibitor with IC50 of 0.1 uM, exhibits excellent selectivity over GIRK1/2 channel.
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GIRK1/4 inhibitor 14b is a potent, brain-sparing GIRK1/4 inhibitor with IC50 of 0.1 uM, exhibits excellent selectivity over GIRK1/2 channel.
GIRK1/4 inhibitor 14b demonstrated targeted clinical exposure of 1.2 μM on AERP in an anesthetized guinea pig model.
GIRK1/4 inhibitor 14b treatment resulted in prolongation of the shortened AERP over a 20 to 30 min time period until steady-state was achieved.
| M.Wt | 445.68 | |
| Formula | C18H15Cl3N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stefan Peukert, et al. Bioorg Med Chem Lett. 2023 Apr 1;85:129237.
2. Patent WO2022074567 A1.
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