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Chemical Structure : GIV3727
Catalog No.: PC-61223Not For Human Use, Lab Use Only.
GIV3727 is a novel potent bitter receptor (TAS2Rs) antagonist that inhibits activation of hTAS2R31 by saccharin and acesulfame K with IC50 of 6.4 and 7.9 uM respectively.
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GIV3727 is a novel potent bitter receptor (TAS2Rs) antagonist that inhibits activation of hTAS2R31 by saccharin and acesulfame K with IC50 of 6.4 and 7.9 uM respectively.
GIV3727 also similarly inhibits hTAS2R43 activated by saccharin and acesulfame K, and inhibits multiple hTAS2Rs (19/25), including hTAS2R31 and 43.
GIV3727 decreases bitter taste intensity in humans, specifically affects only bitter taste perception.
GIV3727 is a useful chemical probe to examine the precise contributions of bitter receptor signaling in non-gustatory systems.
| M.Wt | 198.306 | |
| Formula | C12H22O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Slack JP, et al. Curr Biol. 2010 Jun 22;20(12):1104-9.
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