GJ103 sodium salt | Read-through compound

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Chemical Structure : GJ103 sodium salt

CAS No.: 1459687-96-7

GJ103 sodium salt (GJ 103 sodium salt, GJ-103 sodium salt)

Catalog No.: PC-42333Not For Human Use, Lab Use Only.

GJ103 sodium salt is a novel small molecular read-through (SMRT) compound that can induce read through of nonsense mutations in the ATM gene.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GJ103 sodium salt is a novel small molecular read-through (SMRT) compound that can induce read through of nonsense mutations in the ATM gene.
GJ103 sodium salt induces ATM kinase on both TGA and TAG stop codons and restores ATMpSer1981 autophosphorylation and SMC1pSer966 transphosphorylation in A-T cells.

Physicochemical Properties

M.Wt	364.35418928
Formula	C16H13N4NaO3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	Acetic acid, 2-[[4-(3-methoxyphenyl)-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-, sodium salt (1:1)

References

1. Du L, et al. Mol Ther. 2013 Sep;21(9):1653-60.

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GJ103 sodium salt (GJ 103 sodium salt, GJ-103 sodium salt)

Biological Activity

Physicochemical Properties

References

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