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GK563

Chemical Structure : GK563

CAS No.: 1983928-04-6

GK563 (GK-563;GK 563)

Catalog No.: PC-36137Not For Human Use, Lab Use Only.

GK563 (GK-563) is a potent, selective inhibitor of Ca2+-independent phospholipase A2 (GVIA iPLA2) with IC50 of 1 nM, >20,000-fold selectivity over GIVA cPLA2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GK563 (GK-563) is a potent, selective inhibitor of Ca2+-independent phospholipase A2 (GVIA iPLA2) with IC50 of 1 nM, >20,000-fold selectivity over GIVA cPLA2.
    GK563 reduce β-cell apoptosis induced by proinflammatory cytokines.

    Physicochemical Properties

    M.Wt 246.35
    Formula C16H22O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    trans-3-(4-Phenylbutyl)-4-propyloxetan-2-one

    References

    1. Dedaki C, et al. J Med Chem. 2019 Mar 12. doi: 10.1021/acs.jmedchem.8b01216.

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