GKM-001 | Glucokinase activator | Probechem Biochemicals

Chemical Structure : GKM-001

GKM-001 (GKM001)

Catalog No.: PC-49837Not For Human Use, Lab Use Only.

GKM-001 is a potent, liver-selective small molecule activator of glucokinase (GKA), demonstrates glucose lowering effect without hypoglycemia in normal and type II diabetes mellitus (T2DM).

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Biological Activity

GKM-001 is a potent, liver-selective small molecule activator of glucokinase (GKA) with EC50 of 1.55 and 4.3 uM for human and rat GK, respectively.
GKM-001 demonstrates glucose lowering effect without hypoglycemia in normal and type II diabetes mellitus (T2DM).

Physicochemical Properties

M.Wt	580.02
Formula	C25H20ClF2N3O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-chloro-2-(1-(3,4-difluorobenzyl)-4-(4-(methylsulfonyl)benzyl)-1H-pyrrole-2-carboxamido)thiazol-4-yl)acetic acid

References

1. Patent WO2008149382 A1.

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GKM-001 (GKM001)

Biological Activity

Physicochemical Properties

References

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