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GKM-001

Chemical Structure : GKM-001

CAS No.: 1092375-28-4

GKM-001 (GKM001)

Catalog No.: PC-49837Not For Human Use, Lab Use Only.

GKM-001 is a potent, liver-selective small molecule activator of glucokinase (GKA), demonstrates glucose lowering effect without hypoglycemia in normal and type II diabetes mellitus (T2DM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GKM-001 is a potent, liver-selective small molecule activator of glucokinase (GKA) with EC50 of 1.55 and 4.3 uM for human and rat GK, respectively.
    GKM-001 demonstrates glucose lowering effect without hypoglycemia in normal and type II diabetes mellitus (T2DM).

    Physicochemical Properties

    M.Wt 580.02
    Formula C25H20ClF2N3O5S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(5-chloro-2-(1-(3,4-difluorobenzyl)-4-(4-(methylsulfonyl)benzyl)-1H-pyrrole-2-carboxamido)thiazol-4-yl)acetic acid

    References

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