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GL-1196

Chemical Structure : GL-1196

CAS No.: 591242-70-5

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GL-1196 (GL1196)

Catalog No.: PC-62721Not For Human Use, Lab Use Only.

GL-1196 is a PAK4 inhibitor that effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GL-1196 is a PAK4 inhibitor that effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression.
    GL-1196 prominently inhibits the invasion of human gastric cancer cells in parallel with blockage of the PAK4/LIMK1/cofilin pathway.
    GL-1196 also inhibits the formation of filopodia and induced cell elongation in SGC7901 and BGC823 cells.

    Physicochemical Properties

    M.Wt 398.861
    Formula C20H15ClN2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((4-chlorophenyl)(2-hydroxybenzyl)amino)benzo[d]isothiazole 1,1-dioxide

    References

    1. Zhang J, et al. Int J Mol Sci. 2016 Apr 11;17(4):470.

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