Chemical Structure : GLA-1-1
CAS No.:
1212378-90-9
GLA-1-1
Catalog No.: PC-26490Not For Human Use, Lab Use Only.
GLA-1-1 is a small-molecule agonist of large-conductance Ca²⁺-activated K⁺ (BK) channels with EC50 of 3.4 uM, induces autophagy flux by promoting autophagosome-lysosome fusion.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GLA-1-1 is a small-molecule agonist of large-conductance Ca²⁺-activated K⁺ (BK) channels with EC50 of 3.4 uM, induces autophagy flux by promoting autophagosome-lysosome fusion.
GLA-1-1 reduces autofluorescent deposits and RPE abnormalities in Lamp2a-/- mice as detected by FAF, OCT, and confocal microscopy.
GLA-1-1 preserves retinal structure, RPE morphology, and visual function in Lamp2a-/- mice.
GLA-1-1 attenuates Lamp2a deficiency-associated lipid accumulation in the RPE and reduces Bruch's membrane thickening.
GLA-1-1 restores lysosome-dependent degradative abnormalities in CMA-deficient Lamp2a-/- mice.
Physicochemical Properties
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M.Wt
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341.41
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Formula
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C23H19NO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3aR,4S,9bS)-4-(naphthalen-1-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid
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References
1. Hilal Ahmad Mir, et al. bioRxiv [Preprint]. 2026 Mar 23:2026.03.19.712761.
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