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GLP-1 agonist 1

Chemical Structure : GLP-1 agonist 1

CAS No.: 281208-76-2

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GLP-1 agonist 1 (GLP-1R agonist 1)

Catalog No.: PC-70259Not For Human Use, Lab Use Only.

GLP-1 agonist 1 is a potent, selective GLP-1 receptor agonist with EC50 of 1.4 uM in cAMP functional assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GLP-1 agonist 1 is a potent, selective GLP-1 receptor agonist with EC50 of 1.4 uM in cAMP functional assays.
    GLP-1 agonist 1 does not activate the closely related GLP-2, glucagon, and GIP receptors.
    GLP-1 agonist 1 potentiates glucose-mediated insulin secretion in the CD1 GLP-1 receptor knockout mice.

    Physicochemical Properties

    M.Wt 397.215
    Formula C12H5Cl2F3N4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((6,7-dichloro-3-(trifluoromethyl)quinoxalin-2-yl)thio)-5-methyl-1,3,4-thiadiazole

    References

    1. Knudsen LB, et al. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):937-42.

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