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GLP-26

Chemical Structure : GLP-26

CAS No.: 2133017-36-2

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GLP-26 (GLP26)

Catalog No.: PC-35254Not For Human Use, Lab Use Only.

GLP-26 is a novel potent HBV capsid modulator that reduces secreted HBeAg in HepNTCPDL cells transfected with HBV wild type with EC50 of 0.7 uM.

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Purity & Documentation Purity: 99.20% (HPLC) Select Batch:

Biological Activity

GLP-26 is a novel potent HBV capsid modulator that reduces secreted HBeAg in HepNTCPDL cells transfected with HBV wild type with EC50 of 0.7 uM.
GLP26 is a potent inhibitor of cccDNA formation and HBeAg production against the mutant core T109I, demonstrates synergistic activity with ETV in the HepAD38 system, reducing HBV DNA replication.

Physicochemical Properties

M.Wt 373.36
Formula C19H17F2N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3,4-difluorophenyl)-1,3,5-trimethyl-4-(2-oxo-2-(prop-2-yn-1-ylamino)acetyl)-1H-pyrrole-2-carboxamide

References

1. Nijampatnam B, et al. Curr Opin Chem Biol. 2019 Jun;50:73-79.

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