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Chemical Structure : GLPG0187
CAS No.: 1320346-97-1
Catalog No.: PC-42179Not For Human Use, Lab Use Only.
GLPG0187 (GLPG 0187) is a highly potent, broad spectrum integrin receptor antagonist with IC50 of 1-10 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GLPG0187 (GLPG 0187) is a highly potent, broad spectrum integrin receptor antagonist with IC50 of 1-10 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1.
GLPG0187 significantly inhibits angiogenesis both in vivo and in vitro, osteoclastogenesis in vitro, and bone loss in vivo.
GLPG0187 inhibits de novo formation and progression of bone and visceral metastases in prostate cancer and breast cancer mice models.
| M.Wt | 595.713 | |
| Formula | C29H37N7O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 15 mg/mL |
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| Chemical Name/SMILES |
L-Alanine, 3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]- |
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1. Pujuguet P, et al. Eur J Cancer. 2011;47:S28. doi: 10.1016/S0959-8049(11)72695-8.
2. Cirkel GA, et al. Invest New Drugs. 2016 Apr;34(2):184-92.
3. van der Horst G, et al. Neoplasia. 2011 Jun;13(6):516-25.
4. Reeves KJ, et al. Int J Cancer. 2015 Apr 1;136(7):1731-40.
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