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Chemical Structure : GLPG0974
CAS No.: 1391076-61-1
Catalog No.: PC-62591Not For Human Use, Lab Use Only.
GLPG 0974 is a potent, selective free fatty acid receptor 2 (FFA2, GPR43) antagonist with IC50 of 95 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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GLPG0974 is a potent, selective free fatty acid receptor 2 (FFA2, GPR43) antagonist with IC50 of 95 nM.
GLPG0974 inhibits acetate-induced neutrophil migration strongly in vitro with IC50 of 27 nM.
GLPG0974 demonstrates ability to inhibit a neutrophil-based pharmacodynamic (PD) marker, CD11b activation-specific epitope [AE], in a human whole blood assay.
| M.Wt | 484.995 | |
| Formula | C25H25ClN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl) |
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1. Pizzonero M, et al. J Med Chem. 2014 Dec 11;57(23):10044-57.
2. Sergeev E, et al. J Biol Chem. 2016 Jan 1;291(1):303-17.
3. Namour F, et al. Br J Clin Pharmacol. 2016 Jul;82(1):139-48.
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