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Chemical Structure : GLPG2534
Catalog No.: PC-49845Not For Human Use, Lab Use Only.
GLPG2534 (GLPG 2534) is a potent, selective IRAK4 inhibitor with therapeutic potential in chronic inflammatory skin diseases.
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|---|---|---|---|
| 100 mg | Get quote | ||
| 250 mg | Get quote | ||
| 500 mg | Get quote | ||
| 1 g | Get quote | ||
| 5 g | Get quote |
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GLPG2534 (GLPG 2534) is a potent, selective IRAK4 inhibitor with therapeutic potential in chronic inflammatory skin diseases.
GLPG2534 inhibits TLR and IL-1 responses in primary keratinocytes, granulocytes, and T cells.
GLPG2534 markedly dampened skin inflammation (Il-23-, Il-33-, imiquimod- and MC903-induced) in murine models of psoriasis and atopic dermatitis (AD).
GLPG2534 reversed pathogenic molecular signatures in human lesional psoriasis and atopic dermatitis biopsies.
| M.Wt | 424.46 | |
| Formula | C21H24N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lavazais S, et al. Sci Transl Med. 2023 Feb 15;15(683):eabj3289.
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