Catalog No.: PC-25433Not For Human Use, Lab Use Only.
GLPG4471 (GLPG-4471) is a a potent and selective IRAK4 inhibitor with IC50 of 1.7 nM, potently inhibits CL097-induced TNFα in PBMCs with IC50 of 39.4 nM.
GLPG4471 (GLPG-4471) is a a potent and selective IRAK4 inhibitor with IC50 of 1.7 nM, potently inhibits CL097-induced TNFα in PBMCs with IC50 of 39.4 nM.
GLPG4471 potently inhibits the CL097-induced secretion of TNFα and IFNα in human whole blood stimulated with IC50 of 17.1 and 28.0 nM respectively.
GLPG4471 inhibits mouse IRAK4 with IC50 of 2.4 nM.
GLPG4471 displays excellent kinome selectivity against a panel of 369 kinases at 1 uM.
GLPG4471 (30 mg/kg, b.i.d, ora) lexhibited dose-dependent activity in vivo in the CIA mouse model of rheumatoid arthritis.
