GLS4 (Morphothiadin) is a potent inhibitor of HBV capsid assembly, inhibits HBV replication (EC50=62.24 nM).
GLS4 (Morphothiadin) reduces HBV-DNA levels in HepG.2.2.15 cells (IC50=14 nM), shows efficacy against ADV-resistant HBV mutations.
GLS4 (Morphothiadin) strongly inhibits core gene expression (at 100 to 200 nM), suppresses virus accumulation in the supernantant of HepAD38 cells.
GLS4 (Morphothiadin) inhibits HBV replicative forms in the live, shows strong and sustained suppression of virus DNA in treated mice.
