Chemical Structure : GM47-1
CAS No.:
GM47-1
Catalog No.: PC-26668Not For Human Use, Lab Use Only.
GM47-1 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 1.6 uM and trigger a dose-dependent ATP increase with EC50 of 3 uM in Mycobacterium abscessus.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GM47-1 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 1.6 uM and trigger a dose-dependent ATP increase with EC50 of 3 uM in Mycobacterium abscessus.
GM47-1 also acts as an uncoupler, leading to a decrease in intracellular ATP levels and a cytochrome bcc:aa3-dependent increase in oxygen consumption.
GM47-1 is potent against clinical isolates, bactericidal in vitro, and potent against intracellular Mycobacterium abscessus (Mabs).
GM47-1 blocks trehalose monomycolate (TMM) transport to the outer membrane, and Mabs growth susceptibility is mmpL3 dependent.
GM47-1 induces extracellular ATP release and uncouples respiration, potentiates the activity of β-lactam antibiotics.
Physicochemical Properties
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M.Wt
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323.41
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Formula
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C21H22FNO
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(4-ethoxyphenyl)-N-((4-fluoronaphthalen-1-yl)methyl)ethan-1-amine
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References
1. Singh S, et al. Cell Rep. 2026 Apr 22;45(5):117311.
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